C3b complexation diversifies naturally processed T cell epitopes.
Mol Immunol
; 44(11): 2893-9, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17320958
ABSTRACT
In addition to its well-established role in innate immunity, the complement component C3 is of critical importance in modulating the humoral response. In this study, we examined the effect of C3b linkage to tetanus toxin (TeNT) in the production of antigenic peptides inside human APC. We purified HLA-DR associated peptides isolated either from TeNT or TeNT-C3b pulsed cells. This study revealed that TeNT-C3b derived antigenic peptides are different and more numerous than TeNT derived peptides. This increased production of antigenic peptides correlated with a C3b-induced TeNT modification of proteolysis. These findings argue in favour of a new role for C3b in the modulation of T cell epitope during antigen processing and presentation.
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Base de dados:
MEDLINE
Assunto principal:
Complemento C3b
/
Apresentação de Antígeno
/
Epitopos de Linfócito T
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
França