The putative roles of the ubiquitin/proteasome pathway in resistance to anticancer therapy.
Eur J Cancer
; 43(16): 2330-8, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-17888650
ABSTRACT
The ubiquitin/proteasome (UP) pathway plays a significant role in many important biological functions and alterations in this pathway have been shown to contribute to the pathology of many human diseases, including cancer. Proteasome inhibition has been well established as a rational strategy for the treatment of multiple myeloma and is currently under investigation for the treatment of other haematological malignancies and solid tumours. Recent evidence suggests that proteasome inhibition may also sensitise tumour cells to the actions of both conventional chemotherapy and radiotherapy, suggesting that this pathway may modify clinical response to anticancer therapy. However, conflicting evidence exists as to the roles of the UP pathway in resistance to treatment. This review endeavours to discuss such roles.
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Base de dados:
MEDLINE
Assunto principal:
Resistencia a Medicamentos Antineoplásicos
/
Ubiquitina
/
Complexo de Endopeptidases do Proteassoma
/
Proteínas de Neoplasias
/
Neoplasias
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Reino Unido