Mechanisms of mitochondrial outer membrane permeabilization.
Novartis Found Symp
; 287: 170-6; discussion 176-82, 2007.
Article
em En
| MEDLINE
| ID: mdl-18074638
ABSTRACT
In response to many apoptotic stimuli, Bcl-2 family pro-apoptotic members, such as Bax and Bak, are activated. This results in their oligomerization, permeabilization of the outer mitochondrial membrane, and release of many proteins that are normally confined in the mitochondrial inter-membrane space. Among these proteins are cytochrome c, Smac/DIABLO, OMI/HtrA2, AIF and endonuclease G. Mitochondrial outer membrane permeabilization (MOMP) is also associated with fragmentation of the mitochondrial network. The mechanisms that lead to the oligomerization of proapoptotic members of the Bcl-2 family and to MOMP are still unclear and the role of mitochondrial fission in these events remains elusive.
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Base de dados:
MEDLINE
Assunto principal:
Permeabilidade da Membrana Celular
/
Proteínas Mitocondriais
/
Membranas Mitocondriais
/
Mitocôndrias
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
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