Thiosemicarbazones active against Clostridium difficile.

Costello, Cait; Karpanen, Tarja; Lambert, Peter A; Mistry, Preena; Parker, Katy J; Rathbone, Daniel L; Ren, Jiangmeng; Wheeldon, Laura; Worthington, Tony

Costello, Cait; Karpanen, Tarja; Lambert, Peter A; Mistry, Preena; Parker, Katy J; Rathbone, Daniel L; Ren, Jiangmeng; Wheeldon, Laura; Worthington, Tony.

Afiliação

Costello C; School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.

Bioorg Med Chem Lett ; 18(5): 1708-11, 2008 Mar 01.

Article em En | MEDLINE | ID: mdl-18243694

RESUMO

A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against Clostridium difficile.

Assuntos

Antibacterianos/química; Antibacterianos/farmacologia; Clostridioides difficile/efeitos dos fármacos; Tiossemicarbazonas/química; Tiossemicarbazonas/farmacologia; Testes de Sensibilidade Microbiana; Estrutura Molecular; Relação Estrutura-Atividade

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiossemicarbazonas / Clostridioides difficile / Antibacterianos Idioma: En Ano de publicação: 2008 Tipo de documento: Article

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