A TRIFfic perspective on acute lung injury.
Cell
; 133(2): 208-10, 2008 Apr 18.
Article
em En
| MEDLINE
| ID: mdl-18423191
ABSTRACT
Acute lung injury (ALI) is a leading cause of death in people infected with H5N1 avian influenza virus or the SARS-coronavirus. Imai et al. (2008) now report that ALI is triggered by the signaling of oxidized phospholipids through Toll-like receptor 4 (TLR4) and the adaptor protein TRIF. These findings provide insight into the molecular pathogenesis of ALI, a condition for which treatment options are currently very limited.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Desconforto Respiratório
/
Proteínas Adaptadoras de Transporte Vesicular
/
Receptor 4 Toll-Like
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos