Physiochemical drug properties associated with in vivo toxicological outcomes.
Bioorg Med Chem Lett
; 18(17): 4872-5, 2008 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-18691886
ABSTRACT
Relationships between physicochemical drug properties and toxicity were inferred from a data set consisting of animal in vivo toleration (IVT) studies on 245 preclinical Pfizer compounds; an increased likelihood of toxic events was found for less polar, more lipophilic compounds. This trend held across a wide range of types of toxicity and across a broad swath of chemical space.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Relação Estrutura-Atividade
/
Preparações Farmacêuticas
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos