Should HLA-B*5701 screening be performed in every ethnic group before starting abacavir?
Clin Infect Dis
; 48(3): 365-7, 2009 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-19115972
ABSTRACT
Human leukocyte antigen allele (HLA)-B*5701 is associated with abacavir hypersensitivity. However, the carriage rate of HLA-B*5701 has rarely been studied in Asians. In 534 Korean patients with human immunodeficiency virus infection, HLA-B*5701 status was determined by polymerase chain reaction with HLA-B*5701-specific primers. No patients had the HLA-B*5701 allele (95% confidence interval, 0%-0.7%). This explains the paucity of immunologically confirmed cases of abacavir hypersensitivity in Koreans.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Didesoxinucleosídeos
/
Antígenos HLA-B
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Infecções por HIV
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Hipersensibilidade a Drogas
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article