Systems genetics analysis of cancer susceptibility: from mouse models to humans.
Nat Rev Genet
; 10(9): 651-7, 2009 09.
Article
em En
| MEDLINE
| ID: mdl-19636343
ABSTRACT
Genetic studies of cancer susceptibility have shown that most heritable risk cannot be explained by the main effects of common alleles. This may be due to unknown gene-gene or gene-environment interactions and the complex roles of many genes at different stages of cancer. Studies using mouse models of cancer suggest that methods that integrate genetic analysis and genomic networks with knowledge of cancer biology can help to extend our understanding of heritable cancer susceptibility.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Predisposição Genética para Doença
/
Biologia de Sistemas
/
Neoplasias
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos