Chemokine receptor 5Delta32 mutation reduces the risk of acute rejection in liver transplantation.
Ann Transplant
; 14(3): 36-44, 2009.
Article
em En
| MEDLINE
| ID: mdl-19644158
ABSTRACT
BACKGROUND:
Chemokine receptor 5 (CCR-5) plays a central role in allograft rejection. CCR-5Delta32 mutation results in a non-functioning receptor. Homozygous CCR-5Delta32 patients show a significantly improved kidney graft survival rate compared to CCR-5 wild-type patients. Similar correlations between the CCR-5Delta32 genotype and acute rejection or graft survival rate were shown for heart, lung and islet cell transplantation. MATERIAL/METHODS:
The aim of this study was to examine CCR-5Delta32 and acute rejection after liver transplantation (OLT). 158 OLT patients were genotyped. Data of grafts and patients were collected prospectively into a transplant database.RESULTS:
There were no significant differences between groups regarding patient, donor or graft variables. CCR-5 wild-type patients had explicitly more acute rejection episodes (p=0.086) than patients with the heterozygous or homozygous Delta32-mutation. Homozygous Delta32 patients had no acute rejection episodes. 12.5% of heterozygous patients had one acute rejection episode as opposed to 30.6% of wild-type patients. Only wild-type patients experienced more than one rejection episode.CONCLUSIONS:
Patients with the Delta32-mutation might be candidates for a minimized immunosuppressive therapy. CCR-5 could be relevant as a target for a new therapeutic approach.
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Fígado
/
Receptores CCR5
/
Rejeição de Enxerto
/
Mutação
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha