Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development.
Adv Exp Med Biol
; 650: 133-47, 2009.
Article
em En
| MEDLINE
| ID: mdl-19731807
ABSTRACT
The hallmark of B-cell development is the ordered recombination of immunoglobulin (Ig) genes. Recently, considerable progress has been achieved in assembling gene regulatory networks comprised of signaling components and transcription factors that regulate B-cell development. In this chapter we synthesize experimental evidence to explain how such signaling pathways and transcription factors can orchestrate the ordered recombination of immunoglobulin (Ig) genes. Recombination of antigen-receptor loci is regulated both by the developmentally controlled expression of the Rag1 and Rag2 genes and the accessibility of particular loci and their gene segments to recombination. A new framework has emerged that invokes nuclear compartmentalization, large-scale chromatin dynamics and localized changes in chromatin structure in regulating the accessibility of Ig loci at specific stages of B-cell development. We review this emergent framework and discuss new experimental approaches that will be needed to explore the underlying molecular mechanisms.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Recombinação Genética
/
Genes de Imunoglobulinas
/
Linfócitos B
/
Rearranjo Gênico do Linfócito B
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos