Magnetic resonance imaging biomarkers of ischemic stroke: criteria for the validation of primary imaging biomarkers.
Drug News Perspect
; 22(8): 481-6, 2009 Oct.
Article
em En
| MEDLINE
| ID: mdl-20016857
ABSTRACT
Ischemic stroke is associated with a high rate of disability and death. Establishing valid biomarkers could help accelerate the approval of promising new therapies for stroke. Whereas many serum biomarkers have been evaluated, possible imaging biomarkers of stroke lack validation. Magnetic resonance imaging (MRI) is a very sensitive technique to study acute stroke and MRI parameters have been established to assess the outcome of acute stroke. This review reassesses the criteria for the validation of MRI biomarkers of acute ischemic stroke (MRI-BAS). Seven criteria were used to review the validity of the main MRI-BAS vascular status, lesion volume, reversibility on diffusion-weighted imaging, perfusion alteration, penumbra studied with diffusion-perfusion mismatch, clinical-diffusion mismatch, diffusion-angiography mismatch and hemorrhagic transformation. We analyzed the definitions of these biomarkers and the extent to which each fulfills the criteria for validation and found that few MRI-BAS have been fully validated. Further studies should help to improve the validation of current MRI-BAS and develop new biomarkers.
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Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Isquemia Encefálica
/
Acidente Vascular Cerebral
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Espanha