Expression and prognostic values of Id-1 and Id-3 in gastric adenocarcinoma.
J Surg Res
; 167(2): 258-66, 2011 May 15.
Article
em En
| MEDLINE
| ID: mdl-20080245
ABSTRACT
BACKGROUND:
Id (inhibitor of differentiation/DNA binding)-1 and -3 are involved in neoangiogenesis; they antagonize basic helix-loop-helix proteins, inhibit differentiation, and enhance cell proliferation. The aim of this study was to investigate Id-1 and -3 expression in gastric tumors and their clinical relevance in gastric cancer. MATERIALS ANDMETHODS:
We investigated Id-1 and Id-3 expression in gastric cancer samples by immunohistochemistry and Western blotting, and further analyzed the relationship between expression of Id-1 and Id-3 and clinicopathologic characteristics.RESULTS:
Expression of Id-1 and -3 was found significantly more often in gastric cancers than in matched adjacent nonmalignant tissues. Cancer samples with poor or moderate histologic differentiation showed significantly stronger Id-1 and -3 expression than cancer samples with high differentiation. In cancer samples, strong or moderate expression of Id-3, but not Id-1, was a strong independent predictor for shorter overall survival in multivariate analysis.CONCLUSIONS:
The level of Id-1 and -3 protein expression was associated with the malignant potential of gastric tumors. In cancer samples, stronger Id-1 and -3 expression is associated with poor differentiation and more aggressive behavior of tumor cells, resulting in poor clinical outcome. Consequently, Id-3 might be used to independently predict survival of patients with gastric cancer.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Adenocarcinoma
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Biomarcadores Tumorais
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Proteínas Inibidoras de Diferenciação
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Proteína 1 Inibidora de Diferenciação
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Proteínas de Neoplasias
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article