Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors.
J Med Chem
; 53(4): 1473-82, 2010 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-20121197
ABSTRACT
On the basis of our understanding on the binding interactions of the benzothiophene template within the FIXa active site by X-ray crystallography and molecular modeling studies, we developed our SAR strategy by targeting the 4-position of the template to access the S1 beta and S2-S4 sites. A number of highly selective and potent factor Xa (FXa) and FIXa inhibitors were identified by simple switch of functional groups with conformational changes toward the S2-S4 sites.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tiofenos
/
Fator IXa
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido