Asarone inhibits adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes.
Cell Mol Biol (Noisy-le-grand)
; 56 Suppl: OL1215-22, 2010 Jan 24.
Article
em En
| MEDLINE
| ID: mdl-20158974
ABSTRACT
Asarone is a molecule found in certain plants such as Acorus calamus, the root of which is used in traditional medicine to treat diabetes. We determined the molecular mechanism underlying the anti-diabetic activity of asarone. Treatment of asarone significantly inhibited the differentiation of 3T3-L1 preadipocytes through suppression of expression of the transcription factors, CCAAT/enhancer binding protein-alpha and peroxisome proliferator activated receptor-gamma, which activate adipogenesis. Intracellular triglyceride levels were reduced by asarone in a dose-dependent manner and asarone treatment stimulated the phosphorylation of hormone-sensitive lipase. Together, the present findings indicate that asarone inhibits adipogenesis by down-regulation of PPARgamma and C/EBPalpha and reduces lipid accumulation by stimulation of lipolysis through an increase in hormone-sensitive lipase activity.
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Base de dados:
MEDLINE
Assunto principal:
Adipócitos
/
Adipogenia
/
Hipoglicemiantes
/
Lipólise
/
Anisóis
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article