An international trial of antioxidants in the prevention of preeclampsia (INTAPP).
Am J Obstet Gynecol
; 202(3): 239.e1-239.e10, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-20207239
ABSTRACT
OBJECTIVE:
We sought to investigate whether prenatal vitamin C and E supplementation reduces the incidence of gestational hypertension (GH) and its adverse conditions among high- and low-risk women. STUDYDESIGN:
In a multicenter randomized controlled trial, women were stratified by the risk status and assigned to daily treatment (1 g vitamin C and 400 IU vitamin E) or placebo. The primary outcome was GH and its adverse conditions.RESULTS:
Of the 2647 women randomized, 2363 were included in the analysis. There was no difference in the risk of GH and its adverse conditions between groups (relative risk, 0.99; 95% confidence interval, 0.78-1.26). However, vitamins C and E increased the risk of fetal loss or perinatal death (nonprespecified) as well as preterm prelabor rupture of membranes.CONCLUSION:
Vitamin C and E supplementation did not reduce the rate of preeclampsia or GH, but increased the risk of fetal loss or perinatal death and preterm prelabor rupture of membranes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Ácido Ascórbico
/
Vitamina E
/
Suplementos Nutricionais
/
Antioxidantes
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Canadá