Emphysema as a risk factor for the outcome of surgical resection of lung cancer.
J Korean Med Sci
; 25(8): 1146-51, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20676324
ABSTRACT
It is unclear whether emphysema, regardless of airflow limitation, is a predictive factor associated with survival after lung cancer resection. Therefore, we investigated whether emphysema was a risk factor associated with the outcome after resection for lung cancer. This study enrolled 237 patients with non small cell lung cancer with stage I or II who had surgical removal. Patient outcome was analyzed based on emphysema. Emphysema was found in 43.4% of all patients. Patients with emphysema were predominantly men and smokers, and had a lower body mass index than the patients without emphysema. The patients without emphysema (n=133) survived longer (mean 51.2+/-3.0 vs. 40.6+/-3.1 months, P=0.042) than those with emphysema (n=104). The univariate analysis showed a younger age, higher FEV(1)/FVC, higher body mass index, cancer stage I, and a lower emphysema score were significant predictors of better survival. The multivariate analysis revealed a younger age, higher body mass index, and cancer stage I were independent parameters associated with better survival, however, emphysema was not. This study suggests that unfavorable outcomes after surgical resection of lung cancer should not be attributed to emphysema itself.
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MEDLINE
Assunto principal:
Carcinoma Pulmonar de Células não Pequenas
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Enfisema
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Neoplasias Pulmonares
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article