[A 17-year study of bloodstream infection after liver transplantation: resistance rate, risk factor and mortality of enterococcal bloodstream infections].
Zhonghua Yi Xue Za Zhi
; 90(46): 3279-82, 2010 Dec 14.
Article
em Zh
| MEDLINE
| ID: mdl-21223787
ABSTRACT
OBJECTIVE:
To explore the resistance rate, risk factor and mortality of enterococcal bloodstream infections (BSI) after liver transplantation.METHODS:
From January 1993 to May 2010, a retrospective analysis of enterococcus in liver transplants were conducted.RESULTS:
Fifty-eight BSI occurred in 53 of 695 patients. And a total of 30 enterococci were isolated. Linezolid and glycopeptide antibiotics were the most consistently active against the Enterococcus. The resistance rates to Enterococcus for erythromycin, clindamycin, imipenem, ciprofloxacin, gentamycin and ampicillin-clavulanic acid were all over 70%. The univariate analysis identified the following variables as the risk factors for enterococcal bacteremia retransplantation (P=0.03) and biliary duct complications (P=0.02). Enterococcal bloodstream infection increased the mortality at Day 15. No significant difference was found in the mortality rate at Day 30 and 1 year after enterococcal bacteremia.CONCLUSION:
Enterococcus after liver transplantation is resistant to multiple agents but active to linezolid and glycopeptide antibiotics. The risk factors commonly associated with enterococcal BSI are retransplantation and biliary duct complications. Enterococcal BSI can increase the mortality at Day 15 after liver transplantation.
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Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Transplante de Fígado
/
Infecções por Bactérias Gram-Positivas
/
Bacteriemia
/
Enterococcus faecalis
Idioma:
Zh
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China