Meta-analysis of predictive factors for non-sentinel lymph node metastases in breast cancer patients with a positive SLN.
Eur J Surg Oncol
; 37(4): 290-9, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21316185
ABSTRACT
AIMS:
A meta-analysis was performed to identify the clinicopathological variables most predictive of non-sentinel node (NSN) metastases when the sentinel node is positive.METHODS:
A Medline search was conducted that ultimately identified 56 candidate studies. Original data were abstracted from each study and used to calculate odds ratios. The random-effects model was used to combine odds ratios to determine the strength of the associations.FINDINGS:
The 8 individual characteristics found to be significantly associated with the highest likelihood (odds ratio >2) of NSN metastases are SLN metastases >2mm in size, extracapsular extension in the SLN, >1 positive SLN, ≤1 negative SLN, tumour size >2cm, ratio of positive sentinel nodes >50% and lymphovascular invasion in the primary tumour. The histological method of detection, which is associated with the size of metastases, had a correspondingly high odds ratio.CONCLUSIONS:
We identified 8 factors predictive of NSN metastases that should be recorded and evaluated routinely in SLN databases. These factors should be included in a predictive model that is generally applicable among different populations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Biópsia de Linfonodo Sentinela
/
Excisão de Linfonodo
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Linfonodos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Holanda