The role of GABA in human motor learning.
Curr Biol
; 21(6): 480-4, 2011 Mar 22.
Article
em En
| MEDLINE
| ID: mdl-21376596
ABSTRACT
GABA modification plays an important role in motor cortical plasticity. We therefore hypothesized that interindividual variation in the responsiveness of the GABA system to modification influences learning capacity in healthy adults. We assessed GABA responsiveness by transcranial direct current stimulation (tDCS), an intervention known to decrease GABA. The magnitude of M1 GABA decrease induced by anodal tDCS correlated positively with both the degree of motor learning and the degree of fMRI signal change within the left M1 during learning. This study therefore suggests that the responsiveness of the GABAergic system to modification may be relevant to short-term motor learning behavior and learning-related brain activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido gama-Aminobutírico
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Aprendizagem
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Atividade Motora
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Córtex Motor
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido