Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma.
Asian Pac J Allergy Immunol
; 29(3): 266-72, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-22053597
ABSTRACT
OBJECTIVES:
We sought to determine whether the aryl hydrocarbon receptor (AhR) and interleukin (IL)-22 may be involved in the pathogenesis of the peripheral blood mononuclear cells (PBMCs) in allergic asthmatic patients and whether their expression may be related to the severity of the disease.METHODS:
Blood samples were obtained from each subject with allergic asthma (n =18), controlled asthma (n = 17) and healthy controls (n = 12) respectively. The PBMCs were collected for AhR mRNA detection by real-time quantitative polymerase chain reaction (PCR). The plasma was collected for IL-22 protein detection by enzyme-linked immunosorbent assay (ELISA).RESULTS:
The expression of AhR mRNA in PBMCs and IL-22 protein in plasma of patients with allergic asthma were higher than those in controlled asthma cases and healthy controls. The plasma concentrations of IL-22 had negative correlation with the predicted percentage of forced expiratory volume in the first second (FEV1%) and the percentage of FEV1 and forced vital capacity (FEV1/FVC%) and it was positively correlated with the asthma severity score (ASS) of the asthmatics.CONCLUSION:
Our results suggested that both AhR and IL-22 might be involved in the pathogenesis of allergic asthma in human and the level of IL-22 might have some relationship with the severity of the disease.
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Base de dados:
MEDLINE
Assunto principal:
Asma
/
Leucócitos Mononucleares
/
Interleucinas
/
Receptores de Hidrocarboneto Arílico
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article