Childhood-onset anti-MuSK antibody positive myasthenia gravis demonstrates a distinct clinical course.
Brain Dev
; 34(9): 784-6, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22277190
ABSTRACT
Anti-muscle-specific tyrosine kinase antibody (MuSK-Ab) is the second most frequent autoantibody identified in adult patients with myasthenia gravis (MG). Adult patients with MuSK-Ab demonstrate characteristic clinical features but very little information is available for childhood-onset patients with MuSK-positive MG. We report a childhood-onset female patient with MuSK-positive MG. This patient showed basic clinical features compatible with adult-onset MuSK-positive MG, but some features, including spontaneous improvement, are distinct from those in adult patients. Serial examination of MuSK-Ab titers revealed a gross correlation with clinical severity despite significantly high titers throughout the clinical course. Therefore, childhood-onset MuSK-positive MG may demonstrate a distinct clinical characteristics in the early period of illness.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Receptores Proteína Tirosina Quinases
/
Miastenia Gravis
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Japão