3,4-Diarylpiperidines as potent renin inhibitors.
Bioorg Med Chem Lett
; 22(5): 1953-7, 2012 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-22325946
ABSTRACT
The discovery and SAR of a series of potent renin inhibitors possessing a novel 3,4-diarylpiperidine scaffold are described herein. The resulting compound 38 exhibit low nanomolar plasma renin IC(50), had a clean CYP 3A4 profile and displayed micromolar affinity for the hERG channel. Furthermore, it was found to be efficacious in the double transgenic rat hypertension model and show good to moderate oral bioavailability in two animal species.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Renina
/
Hipertensão
/
Anti-Hipertensivos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article