Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines.
PLoS Biol
; 10(2): e1001255, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22346732
ABSTRACT
There is heterogeneity in invariant natural killer T (iNKT) cells based on the expression of CD4 and the IL-17 receptor B (IL-17RB), a receptor for IL-25 which is a key factor in T(H)2 immunity. However, the development pathway and precise function of these iNKT cell subtypes remain unknown. IL-17RBâºiNKT cells are present in the thymic CD44âº/â» NK1.1â» population and develop normally even in the absence of IL-15, which is required for maturation and homeostasis of IL-17RBâ»iNKT cells producing IFN-γ. These results suggest that iNKT cells contain at least two subtypes, IL-17RB⺠and IL-17RBâ» subsets. The IL-17RBâºiNKT subtypes can be further divided into two subtypes on the basis of CD4 expression both in the thymus and in the periphery. CD4⺠IL-17RBâºiNKT cells produce T(H)2 (IL-13), T(H)9 (IL-9 and IL-10), and T(H)17 (IL-17A and IL-22) cytokines in response to IL-25 in an E4BP4-dependent fashion, whereas CD4â» IL-17RBâºiNKT cells are a retinoic acid receptor-related orphan receptor (ROR)γt⺠subset producing T(H)17 cytokines upon stimulation with IL-23 in an E4BP4-independent fashion. These IL-17RBâºiNKT cell subtypes are abundantly present in the lung in the steady state and mediate the pathogenesis in virus-induced airway hyperreactivity (AHR). In this study we demonstrated that the IL-17RBâºiNKT cell subsets develop distinct from classical iNKT cell developmental stages in the thymus and play important roles in the pathogenesis of airway diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Subpopulações de Linfócitos T
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Células T Matadoras Naturais
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Japão