The topography of brain damage at different stages of Parkinson's disease.
Hum Brain Mapp
; 34(11): 2798-807, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-22528144
ABSTRACT
This study investigated gray matter (GM) and white matter (WM) damage in 89 patients at different clinical stages of Parkinson's disease (PD) (17 early, 46 mild, 14 moderate, and 12 severe) to differentiate the trajectories of tissue injury in this condition. PD patients had a very little GM atrophy even at the more advanced stages of the disease. Microstructural damage to the WM occurs with increasing PD severity and involves the brainstem, thalamocortical pathways, olfactory tracts, as well as the major interhemispheric, limbic, and extramotor association tracts. The most marked WM damage was found in moderate vs. mild cases. WM damage correlated with the degree of global cognitive deficits. WM abnormalities beyond the nigrostriatal system accumulate with increasing PD severity. WM damage is likely to contribute to the more severe motor and nonmotor dysfunctions occurring in patients at the later stages.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
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Encéfalo
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Dano Encefálico Crônico
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Mapeamento Encefálico
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália