Perifosine sensitizes UVB-induced apoptosis in skin cells: new implication of skin cancer prevention?
Cell Signal
; 24(9): 1781-9, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22584119
ABSTRACT
We demonstrate here that a relative low dose of perifosine significantly enhanced UVB-induced apoptosis in skin cells (keratinocytes and fibroblasts), associated with a significant increase of reactive oxygen species (ROS) and ceramide production as well as multiple perturbations of diverse cell signaling pathways, shifting to a significant pro-apoptosis outcomes. Perifosine inhibited UVB-induced pro-survival Akt/mammalian target of rapamycin (mTOR) and ERK activation, while facilitating pro-apoptotic AMP-activated protein kinas (AMPK), c-Jun-NH(2)-kinase (JNK), and p53 activation; these signaling changes together promoted a striking increase in skin cell apoptosis and a significantly reduced amount of DNA damages. Our results suggest that perifosine may represent a novel skin cancer prevention strategy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosforilcolina
/
Pele
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Neoplasias Cutâneas
/
Raios Ultravioleta
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Apoptose
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China