Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.
Nat Chem Biol
; 8(9): 745-7, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22797665
ABSTRACT
Here we report AWP28, an activity-based probe that can be used to biochemically monitor caspase-1 activation in response to proinflammatory stimuli. Using AWP28, we show that apoptosis is triggered upon Salmonella enterica var. Typhimurium infection in primary mouse bone marrow macrophages lacking caspase-1. Furthermore, we report that upon Salmonella infection, inflammasome-mediated caspase-1 activity is required to bypass apoptosis in favor of proinflammatory pyroptotic cell death.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por Salmonella
/
Apoptose
/
Caspase 1
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Macrófagos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos