MMP7 is a target of the tumour-associated antigen EpCAM.
Int J Exp Pathol
; 93(5): 341-53, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22974215
ABSTRACT
Epithelial cell adhesion molecule (EpCAM) is a single-transmembrane protein, which is involved in numerous cellular processes including cell adhesion, proliferation, maintenance of stemness of embryonic cells and progenitors, migration and invasion. Activation of signal transduction by EpCAM is warranted by regulated intramembrane proteolysis and nuclear translocation of the intracellular domain EpICD. Here, we describe matrix metalloproteinase 7 (MMP7) as a target gene of EpCAM signalling viaEpICD nuclear translocation. EpCAM and MMP7 expression pattern and levels positively correlated in vitro and in vivo, and were strongly elevated in primary carcinomas of the head and neck area. Hence, MMP7 is a novel target of EpCAM signalling.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
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Transdução de Sinais
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Moléculas de Adesão Celular
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Metaloproteinase 7 da Matriz
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Neoplasias de Cabeça e Pescoço
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Antígenos de Neoplasias
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Alemanha