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Treatment of candidiasis: insights from host genetics.
Delsing, Corine E; Bleeker-Rovers, Chantal P; Kullberg, Bart-Jan; Netea, Mihai G.
Afiliação
  • Delsing CE; Department of Internal Medicine, Radboud University Nijmegen MedicalCenter, P O Box 9101, 6500HB Nijmegen, The Netherlands. c.delsing@aig.umcn.nl
Expert Rev Anti Infect Ther ; 10(8): 947-56, 2012 Aug.
Article em En | MEDLINE | ID: mdl-23030333
Candida species are major causes of mucosal and invasive infections, leading to substantial morbidity and mortality. Despite the development of new classes of antifungal drugs, mortality in patients with systemic candidiasis remains high. Host-Candida interaction plays an important role in effective elimination of the pathogen. Genetic studies have rendered important insights into antifungal host defense and have identified potential targets for adjunctive therapy. In this article, the authors review the genetic variations in the host defense to Candida and their implications for the treatment of mucosal and systemic candidiasis.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Candida / Candidíase / Antifúngicos Idioma: En Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Candida / Candidíase / Antifúngicos Idioma: En Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Holanda