Inefficient vaginal transmission of tenofovir-resistant HIV-1.
J Virol
; 87(2): 1274-7, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-23115295
ABSTRACT
Transmission of drug-resistant HIV has been postulated to be a threat to current first-line antiretroviral therapy (ART) regimens and the efficacy of several antiretroviral-based preexposure prophylaxis (PrEP) strategies being tested. Here we evaluated the effect of the common tenofovir (TFV) resistance mutation K65R on vaginal HIV transmission. Our results demonstrate that despite no overt loss of overall replication competence in vivo, this mutation results in significantly reduced mucosal transmission. When transmitted, the mutant virus eventually reverted to the wild type in 2 of 3 animals examined.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adenina
/
Infecções por HIV
/
HIV-1
/
Fármacos Anti-HIV
/
Mutação de Sentido Incorreto
/
Farmacorresistência Viral
/
Organofosfonatos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos