Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I.
Bioorg Med Chem Lett
; 22(24): 7702-6, 2012 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-23142617
ABSTRACT
The discovery of potent small molecule dual antagonists of the human CCR3 and H(1) receptors is described for the treatment of allergic diseases, for example, asthma and allergic rhinitis. Optimizing in vitro potency and metabolic stability, starting from a CCR1 lead compound, led to compound 20 with potent dual CCR3/H(1) activity and in vitro metabolic stability.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Receptores Histamínicos H1
/
Receptores CCR3
/
Descoberta de Drogas
/
Ácidos Hidroxâmicos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Suécia