Microbial modulation of host immunity with the small molecule phosphorylcholine.
Infect Immun
; 81(2): 392-401, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23230294
ABSTRACT
All microorganisms dependent on persistence in a host for survival rely on either hiding from or modulating host responses to infection. The small molecule phosphorylcholine, or choline phosphate (ChoP), is used for both of these purposes by a wide array of bacterial and parasitic microbes. While the mechanisms underlying ChoP acquisition and expression are diverse, a unifying theme is the use of ChoP to reduce the immune response to infection, creating an advantage for ChoP-expressing microorganisms. In this minireview, we discuss several benefits of ChoP expression during infection as well as how the immune system fights back against ChoP-expressing pathogens.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosforilcolina
/
Bactérias
/
Interações Hospedeiro-Patógeno
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos