Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2.
Bioorg Med Chem Lett
; 23(7): 2220-4, 2013 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-23434415
ABSTRACT
Sphingosine kinase (SPHK), which catalyzes the phosphorylation of sphingosine to generate sphingosine 1-phosphate, has two mammalian isotypes, SPHK1 and SPHK2. Both isozymes are promising anti-cancer therapeutic targets. In this report, we found that SG-12, a synthetic analogue of sphingosine that acts as a SPHK2 inhibitor, induces apoptosis via phosphorylation by SPHK2. The present results revealed the novel anti-cancer potential of a sphingosine analogue in the pathological setting where SPHK2 is upregulated.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esfingosina
/
Apoptose
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Fosfotransferases (Aceptor do Grupo Álcool)
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Inibidores de Proteínas Quinases
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Antineoplásicos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Japão