Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis.
Gynecol Endocrinol
; 29(5): 455-9, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23461865
ABSTRACT
The aim of this study was to evaluate serum and peritoneal fluid (PF) glycodelin-A concentrations in women with ovarian endometriosis. Ninety-nine matched pairs of serum and PF samples were included in our study. The case group comprised 57 women with ovarian endometriosis and the control group 42 healthy women undergoing sterilization or patients with benign ovarian cysts. Glycodelin-A concentrations were measured using ELISA. Endometriosis patients had significantly higher serum and PF glycodelin-A concentrations compared to controls, and this increase was observed in both proliferative and secretory cycle phases. Glycodelin-A concentrations were more than 10-fold higher in PF than in serum and correlated with each other. Intensity and frequency of menstrual pain positively correlated with glycodelin-A concentrations. Sensitivity and specificity of glycodelin-A as a biomarker for ovarian endometriosis were 82.1% and 78.4% in serum, and 79.7% and 77.5% in PF, respectively. These results indicate that Glycodelin-A has a potential role as a biomarker to be used in combination with other, independent marker molecules.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Ovarianas
/
Líquido Ascítico
/
Glicoproteínas
/
Endometriose
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Eslovênia