Beneficial effect of dehydroepiandrosterone on pulmonary hypertension in a rodent model of pulmonary hypertension in infants.
Pediatr Res
; 74(2): 163-9, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23648417
ABSTRACT
BACKGROUND:
Pulmonary hypertension (PH) is a disease that affects the adult or infant population. Dehydroepiandrosterone (DHEA), a steroid hormone, has been previously shown to prevent and to reverse PH in an adult rat model. We thus investigated its effect in a rat-pup model of chronic hypoxic PH.METHODS:
Animals were maintained for 3 wk in a hypobaric chamber to induce PH, with or without concomitant treatment with DHEA (30 mg/kg every alternate day).RESULTS:
DHEA significantly reduced mean pulmonary artery pressure (measured by right cardiac catheterization), pulmonary artery remodeling (evaluated by histology), and right-ventricular hypertrophy (measured by echography and by the Fulton index). At the level of the pulmonary artery smooth muscle cell (PASMC), DHEA increased activity and expression of the large-conductance Ca2+-activated potassium channel (BKCa) (assessed by means of the patch clamp technique). DHEA also inhibited both serotonin- and KCl-induced contraction and smooth muscle cell proliferation.CONCLUSION:
Collectively, these results indicate that DHEA prevents PH in infant rats and may therefore be clinically relevant for the management of PH in human infants.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Desidroepiandrosterona
/
Miócitos de Músculo Liso
/
Hipertensão Pulmonar
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
França