Plants from northeast Mexico with anti-HSV activity.
Nat Prod Commun
; 8(3): 297-8, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23678795
ABSTRACT
Based on chemotaxonomic and ethno-pharmacological criteria, three Mexican plants (Jatropha dioica, Salvia texana and S. ballotaeflora) were studied for in vitro activity against HSV-1 and HSV-2. Hydro-methanolic extracts were initially evaluated for their toxicity to Vero cells. Both Salvia species displayed cytotoxicity at the lowest dose (125 microg/mL). The J. dioica extract showed only negligible cytotoxicity (CC50 644 microg/mL). Its anti-HSV activity was evaluated using the plaque reduction assay with HSV-1 and HSV-2 (from clinical isolates) infected Vero cells. The hydro-methanolic extract of J. dioica showed IC50s of 280 and 370 microg/mL against HSV-1 and HSV-2, respectively. The n-hexane liquid-liquid partition of J. dioica extract contained the majority of the active principle(s) with IC50 values of 300 and 270 microg/mL for HSV-1 and HSV-2, respectively. Bioassay-guided isolation led to the known diterpene, riolozatrione.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Herpesvirus Humano 2
/
Herpesvirus Humano 1
/
Salvia
/
Jatropha
País/Região como assunto:
Mexico
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article