CXI-benzo-84 reversibly binds to tubulin at colchicine site and induces apoptosis in cancer cells.
Biochem Pharmacol
; 86(3): 378-91, 2013 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-23747346
Palavras-chave
(N-(2-(piperidin-1-yl)phenyl)-2-(thiophen-2-yl)-1H-benzo[d]imidazole-4-carboxamide); Anticancer drug; Apoptosis; Benzimidazole; CXI-benzo-84; Cell cycle; Checkpoint proteins; DAMA-colchicine; DMSO; EGTA; GTP; Microtubule assembly dynamics; N-deacetyl-N-(2-mercaptoacetyl) colchicine; PBS; PI; PIPES; SRB; TCA; dimethyl sulfoxide; ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid; guanosine-5'-triphosphate; phosphate buffered saline; piperazine-N,N'-bis(2-ethanesulfonic acid); propidium iodide; sulforhodamine B; trichloro acetic acid
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tubulina (Proteína)
/
Benzimidazóis
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Colchicina
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Apoptose
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Anilidas
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Índia