[IgG4-related disease]. / Maladie associée aux immunoglobulines G de type 4.
Rev Prat
; 63(5): 605-10, 2013 May.
Article
em Fr
| MEDLINE
| ID: mdl-23789481
ABSTRACT
IgG4-related disease is an emerging pathological condition characterized by one or several fibrosing and inflammatory organ involvements. Histological findings are typical and associate storiform fibrosis with polyclonal lymphocytic and plasma-cell infiltrate, with predominant IgG4-expressing plasma cells. Sclerosing lymphoplasmocytic pancreatitis, or type 1 auto-immune pancreatitis, and other organ involvements have been reported sclerosing cholangitis, sialadenitis, dacryoadenitis, retroperitoneal fibrosis, aortitis, interstitial nephritis, polyadenopathy and inflammatory pseudo-tumors. Serum IgG4 level is elevated in most of patients, but the histological documentation remain necessary for the diagnosis. Dramatic response to steroids is usual but relapses are frequent.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Imunoglobulina G
Idioma:
Fr
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
França