A new nucleic acid-based agent inhibits cytotoxic T lymphocyte-mediated immune disorders.

Wang, Chuang-Wei; Chung, Wen-Hung; Cheng, Yi-Fang; Ying, Nien-Wen; Peck, Konan; Chen, Yuan-Tsong; Hung, Shuen-Iu

Wang, Chuang-Wei; Chung, Wen-Hung; Cheng, Yi-Fang; Ying, Nien-Wen; Peck, Konan; Chen, Yuan-Tsong; Hung, Shuen-Iu.

Afiliação

Wang CW; Department and Institute of Pharmacology, School of Medicine, Infection and Immunity Research Center, National Yang-Ming University, Taipei, Taiwan; Molecular Medicine Program, National Yang-Ming University and Academia Sinica, Taipei, Taiwan.
Chung WH; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospitals, Keelung, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Cheng YF; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan.
Ying NW; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan.
Peck K; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan.
Chen YT; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan.
Hung SI; Department and Institute of Pharmacology, School of Medicine, Infection and Immunity Research Center, National Yang-Ming University, Taipei, Taiwan; Molecular Medicine Program, National Yang-Ming University and Academia Sinica, Taipei, Taiwan. Electronic address: sihung@ym.edu.tw.

J Allergy Clin Immunol ; 132(3): 713-722.e11, 2013 Sep.

Article em En | MEDLINE | ID: mdl-23791505

Assuntos

Antígenos de Diferenciação de Linfócitos T/genética; Aptâmeros de Nucleotídeos/administração & dosagem; Antígenos CD8/genética; RNA Interferente Pequeno/administração & dosagem; Linfócitos T Citotóxicos/imunologia; Doença Enxerto-Hospedeiro/imunologia; Humanos; Síndrome de Stevens-Johnson/imunologia

Palavras-chave

Alloreactivity; CD8; CON; CTL; Cytotoxic T lymphocyte; Dissociation constant; GNLY; GVHD; Graft-versus-host disease; Granulysin; K(d); NF-κB; NK; Natural killer; Nonsilencing control; Nuclear factor κB; RNA interference; RNAi; SEAP; SELEX; SJS; Secreted embryonic alkaline phosphatase; Single-stranded DNA; Small interfering RNA; Stevens-Johnson syndrome; Systematic evolution of ligands by exponential enrichment; T-cell receptor; TCR; TEN; Toxic epidermal necrolysis; aptamer; drug hypersensitivity; graft-versus-host disease; granulysin; nucleic acidbased therapeutics; siRNA; ssDNA; systematic evolution of ligands by exponential enrichment; toxic epidermal necrolysis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T Citotóxicos / Antígenos de Diferenciação de Linfócitos T / Antígenos CD8 / RNA Interferente Pequeno / Aptâmeros de Nucleotídeos Idioma: En Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Taiwan

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