Piezo1 plays a role in erythrocyte volume homeostasis.
Haematologica
; 99(1): 70-5, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-23872304
ABSTRACT
Mechanosensitivity is an inherent property of virtually all cell types, allowing them to sense and respond to physical environmental stimuli. Stretch-activated ion channels represent a class of mechanosensitive proteins which allow cells to respond rapidly to changes in membrane tension; however their identity has remained elusive. The piezo genes have recently been identified as a family of stretch-activated mechanosensitive ion channels. We set out to determine the role of piezo1 during zebrafish development. Here we report that morpholino-mediated knockdown of piezo1 impairs erythrocyte survival without affecting hematopoiesis or differentiation. Our results demonstrate that piezo1 is involved in erythrocyte volume homeostasis, disruption of which results in swelling/lysis of red blood cells and consequent anemia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peixe-Zebra
/
Proteínas de Peixe-Zebra
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Volume de Eritrócitos
/
Homeostase
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Canais Iônicos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article