Two different hypofractionated breast radiotherapy schedules for 113 patients with ductal carcinoma in situ: preliminary results.
Anticancer Res
; 33(8): 3503-7, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23898126
ABSTRACT
AIM:
To assess local control and cosmetic outcomes for two different hypofractionated radiotherapy schedules after breast-conserving surgery for ductal carcinoma in situ (DCIS). PATIENTS ANDMETHODS:
A total of 113 breast-conserving operated patients with DCIS were treated from August 2006 to August 2011 41 women received 46 Gy in 20 fractions of 2.3 Gy four times a week, for five weeks; the other 72 patients received 39 Gy in 13 fractions of 3 Gy four times a week for 3.5 weeks. Both schedules involved a concomitant boost to the tumor bed, with dose adjustment according to the surgical margins.RESULTS:
The median follow-up is 30.5 months. Overall, the treatments were well-tolerated. The most common acute effect was erythema grade 1 in 56.1% and 31.9% in the longer and in the shorter hypofractionated treatment, grade 2 in 9.8% and 0% of cases respectively. Late toxicity of fibrosis occurred at grade 1 in 19.6% and 15.3% respectively and at grade 2 in 0% and 2.8%.CONCLUSION:
These results suggest that patients with DCIS can be safely treated with a shorter radiotherapy regimen.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Carcinoma Intraductal não Infiltrante
/
Fracionamento da Dose de Radiação
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália