Clustered protocadherins.
Development
; 140(16): 3297-302, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23900538
ABSTRACT
The majority of vertebrate protocadherin (Pcdh) genes are clustered in a single genomic locus, and this remarkable genomic organization is highly conserved from teleosts to humans. These clustered Pcdhs are differentially expressed in individual neurons, they engage in homophilic trans-interactions as multimers and they are required for diverse neurodevelopmental processes, including neurite self-avoidance. Here, we provide a concise overview of the molecular and cellular biology of clustered Pcdhs, highlighting how they generate single cell diversity in the vertebrate nervous system and how such diversity may be used in neural circuit assembly.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células de Purkinje
/
Caderinas
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Família Multigênica
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Vias Neurais
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos