Adult neurogenesis produces neurons with unique GABAergic synapses in the olfactory bulb.
J Neurosci
; 33(37): 14660-5, 2013 Sep 11.
Article
em En
| MEDLINE
| ID: mdl-24027267
ABSTRACT
Neuronal regeneration occurs naturally in a few restricted mammalian brain regions, but its functional significance remains debated. Here we search for unique features in the synaptic outputs made by adult-born granule cell interneurons in the mouse olfactory bulb using optogenetic targeting of specific neuronal ages. We find that adult-born interneurons are resistant to presynaptic GABA(B)-mediated depression of GABA release compared with interneurons born just after birth that exhibit strong GABA(B) neuromodulation. Correlated with this functional change, we found altered localization of the GGABA(B)R1 protein within adult-born granule cells. These results suggest that adult neurogenesis produces a population of functionally unique GABAergic synapses in the olfactory bulb.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bulbo Olfatório
/
Sinapses
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Células-Tronco Adultas
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Neurogênese
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Neurônios GABAérgicos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
França