Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges.

Scharf, Daniel H; Chankhamjon, Pranatchareeya; Scherlach, Kirstin; Heinekamp, Thorsten; Willing, Karsten; Brakhage, Axel A; Hertweck, Christian

Scharf, Daniel H; Chankhamjon, Pranatchareeya; Scherlach, Kirstin; Heinekamp, Thorsten; Willing, Karsten; Brakhage, Axel A; Hertweck, Christian.

Afiliação

Scharf DH; Depts. of Molecular and Applied Microbiology, Biomolecular Chemistry, and Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena (Germany).

Angew Chem Int Ed Engl ; 52(42): 11092-5, 2013 Oct 11.

Article em En | MEDLINE | ID: mdl-24039048

Assuntos

Aspergillus fumigatus/metabolismo; Dissulfetos/metabolismo; Glutationa/metabolismo; Piperazinas/metabolismo; Aspergillus fumigatus/enzimologia; Dipeptidases/metabolismo; Gliotoxina/biossíntese; Gliotoxina/metabolismo; Glutationa/biossíntese; Modelos Moleculares; Piperazinas/síntese química; Piperazinas/química

Palavras-chave

Aspergillus fumigatus; biosynthesis; dipeptidase; gliotoxin; mycotoxins

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Aspergillus fumigatus / Dissulfetos / Glutationa Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google