Nonicosahedral pathways for capsid expansion.
Phys Rev E Stat Nonlin Soft Matter Phys
; 88(3): 032710, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-24125297
ABSTRACT
For a significant number of viruses a structural transition of the protein container that encapsulates the viral genome forms an important part of the life cycle and is a prerequisite for the particle becoming infectious. Despite many recent efforts the mechanism of this process is still not fully understood, and a complete characterization of the expansion pathways is still lacking. We present here a coarse-grained model that captures the essential features of the expansion process and allows us to investigate the conditions under which a viral capsid becomes unstable. Based on this model we demonstrate that the structural transitions in icosahedral viral capsids are likely to occur through a low-symmetry cascade of local expansion events spreading in a wavelike manner over the capsid surface.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Modelos Moleculares
/
Capsídeo
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália