CNS inflammation and bone marrow neuropathy in type 1 diabetes.
Am J Pathol
; 183(5): 1608-20, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24160325
ABSTRACT
By using pseudorabies virus expressing green fluorescence protein, we found that efferent bone marrow-neural connections trace to sympathetic centers of the central nervous system in normal mice. However, this was markedly reduced in type 1 diabetes, suggesting a significant loss of bone marrow innervation. This loss of innervation was associated with a change in hematopoiesis toward generation of more monocytes and an altered diurnal release of monocytes in rodents and patients with type 1 diabetes. In the hypothalamus and granular insular cortex of mice with type 1 diabetes, bone marrow-derived microglia/macrophages were activated and found at a greater density than in controls. Infiltration of CD45(+)/CCR2(+)/GR-1(+)/Iba-1(+) bone marrow-derived monocytes into the hypothalamus could be mitigated by treatment with minocycline, an anti-inflammatory agent capable of crossing the blood-brain barrier. Our studies suggest that targeting central inflammation may facilitate management of microvascular complications.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
/
Sistema Nervoso Central
/
Diabetes Mellitus Tipo 1
/
Inflamação
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Austrália