Colestase/induzido quimicamente; Hepatócitos/efeitos dos fármacos; Xenobióticos/toxicidade; Animais; Células Cultivadas; Colestase/patologia; Relação Dose-Resposta a Droga; Hepatócitos/patologia; Humanos; Ratos

ALP; ALT; BAs; BSEP/Bsep; Bile acids; Bile salt export pump; CA; DICI; DMSO; Drug-induced cholestasis; FBS; GCDCA; GDCA; HBSS; Hanks' balanced salt solution; NOAEL; NTCP/Ntcp; PBS; SCH; SCHH; SCRH; SM; Safety margin; Sandwich-cultured hepatocytes; TCA; ULN; Urea assay; alanine aminotransferase; aspartate aminotransferase; bile acids; bile salt export pump (human/rat); cholic acid; dimethyl sulfoxide; drug-induced cholestasis index; fetal bovine serum; glycochenodeoxycholic acid; glycodeoxycholic acid; no observed adverse effect level; phosphate buffered saline; safety margin; sandwich-cultured hepatocytes; sandwich-cultured human hepatocytes; sandwich-cultured rat hepatocytes; sodium taurocholate cotransporting polypeptide (human/rat); taurocholic acid; upper limit of normal