Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors.
EMBO Rep
; 15(1): 103-9, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24357660
ABSTRACT
The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand-gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long-standing question. Here, we show that GluD2 gating is triggered by type 1 metabotropic glutamate receptors, both in a heterologous expression system and in Purkinje cells. Thus, GluD2 is not only an adhesion molecule at synapses but also works as a channel. This gating mechanism reveals new properties of glutamate receptors that emerge from their interaction and opens unexpected perspectives regarding synaptic transmission and plasticity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Glutamato
/
Receptores de Glutamato Metabotrópico
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
França