Down-regulated peroxisome proliferator-activated receptor Î³ (PPARÎ³) in lung epithelial cells promotes a PPARÎ³ agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD).

Lakshmi, Sowmya P; Reddy, Aravind T; Zhang, Yingze; Sciurba, Frank C; Mallampalli, Rama K; Duncan, Steven R; Reddy, Raju C

Lakshmi, Sowmya P; Reddy, Aravind T; Zhang, Yingze; Sciurba, Frank C; Mallampalli, Rama K; Duncan, Steven R; Reddy, Raju C.

Afiliação

Lakshmi SP; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240.
Reddy AT; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240.
Zhang Y; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Sciurba FC; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Mallampalli RK; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240.
Duncan SR; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Reddy RC; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240. Electronic address: reddyrc@upmc.edu.

J Biol Chem ; 289(10): 6383-6393, 2014 Mar 07.

Article em En | MEDLINE | ID: mdl-24368768

Assuntos

Anti-Inflamatórios não Esteroides/farmacologia; Pulmão/efeitos dos fármacos; Ácidos Oleicos/farmacologia; PPAR gama/agonistas; Doença Pulmonar Obstrutiva Crônica/metabolismo; Mucosa Respiratória/efeitos dos fármacos; Tiazolidinedionas/farmacologia; Brônquios/efeitos dos fármacos; Brônquios/metabolismo; Brônquios/patologia; Células Cultivadas; Regulação para Baixo; Resistência a Medicamentos; Técnicas de Silenciamento de Genes; Histona Desacetilase 2/antagonistas & inibidores; Humanos; Pulmão/metabolismo; Pulmão/patologia; NF-kappa B/metabolismo; Estresse Oxidativo/efeitos dos fármacos; PPAR gama/antagonistas & inibidores; PPAR gama/genética; Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico; Doença Pulmonar Obstrutiva Crônica/patologia; Mucosa Respiratória/metabolismo; Mucosa Respiratória/patologia; Rosiglitazona; Fumar/efeitos adversos; Fumar/metabolismo; Fumar/patologia

Palavras-chave

Chromatin Histone Modification; Cigarette Smoke; Glucocorticoid Receptor; Histone Deacetylase; Human Bronchial Epithelial Cells; I-kappa-B Kinase; Inflammation; NF-kappa B (NF-KB); Oxidative Stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Oleicos / Anti-Inflamatórios não Esteroides / Mucosa Respiratória / Doença Pulmonar Obstrutiva Crônica / Tiazolidinedionas / PPAR gama / Pulmão Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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