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Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3.
Butler, Christopher F; Peet, Caroline; McLean, Kirsty J; Baynham, Michael T; Blankley, Richard T; Fisher, Karl; Rigby, Stephen E J; Leys, David; Voice, Michael W; Munro, Andrew W.
Afiliação
  • Butler CF; *Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
  • Peet C; †Cypex Ltd, 6 Tom McDonald Avenue, Dundee DD2 1NH, U.K.
  • McLean KJ; *Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
  • Baynham MT; ‡Agilent Technologies UK Ltd, Lakeside, Cheadle Royal Business Park, Stockport, Cheshire SK8 3GR, U.K.
  • Blankley RT; ‡Agilent Technologies UK Ltd, Lakeside, Cheadle Royal Business Park, Stockport, Cheshire SK8 3GR, U.K.
  • Fisher K; *Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
  • Rigby SE; *Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
  • Leys D; *Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
  • Voice MW; †Cypex Ltd, 6 Tom McDonald Avenue, Dundee DD2 1NH, U.K.
  • Munro AW; *Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
Biochem J ; 460(2): 247-59, 2014 Jun 01.
Article em En | MEDLINE | ID: mdl-24588219
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bacillus megaterium / Proteínas de Bactérias / NADPH-Ferri-Hemoproteína Redutase / Sistema Enzimático do Citocromo P-450 / Inibidores da Bomba de Prótons Idioma: En Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bacillus megaterium / Proteínas de Bactérias / NADPH-Ferri-Hemoproteína Redutase / Sistema Enzimático do Citocromo P-450 / Inibidores da Bomba de Prótons Idioma: En Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido