The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development.
Trends Parasitol
; 30(4): 170-5, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24636355
ABSTRACT
We hypothesise that intraerythrocytic malaria parasite metabolism is not merely fulfilling the need for ATP generation, but is evolved to support rapid proliferation, similar to that seen in other rapidly proliferating cells such as cancer cells. Deregulated glycolytic activity coupled with impaired mitochondrial metabolism is a metabolic strategy to generate glycolytic intermediates essential for rapid biomass generation for schizogony. Further, we discuss the possibility that Plasmodium metabolism is not only a functional consequence of the 'hard-wired' genome and argue that metabolism may also have a causal role in triggering the cascade of events that leads to developmental stage transitions. This hypothesis offers a framework to rationalise the observations of aerobic glycolysis, atypical mitochondrial metabolism, and metabolic switching in nonproliferating stages.
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Base de dados:
MEDLINE
Assunto principal:
Plasmodium
/
Interações Hospedeiro-Parasita
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Reino Unido